Lead Python Full-Stack Engineer

EPAM SystemsAmsterdamHybridFull-time23 Sept 2026

Lead Python Full-Stack Engineer needed for a hybrid role in the Netherlands, building scalable cloud-native applications with integrated AI/ML capabilities. Requires 5+ years of Python backend experience, frontend skills in React.js and TypeScript, and hands-on LLM-based solution implementation.

What you'll do

Design, develop, and optimize Python-based backend services using frameworks such as FastAPI or Django
Build responsive, user-focused frontend interfaces leveraging React.js and TypeScript
Develop and integrate RESTful/GraphQL APIs and microservices into cloud-native architectures
Implement AI/ML features and LLM-based solutions in production systems
Apply industry best practices: testing strategies, code reviews, CI/CD pipeline management
Work within Microsoft Azure and containerized environments (Docker, Kubernetes)
Collaborate with cross-functional teams to deliver full-stack features aligned with delivery goals
Participate in architecture discussions and contribute to technical decisions
Ensure observability, performance tuning and cost optimization for deployed applications

What you need

Must-have

PythonFastAPIDjangoReact.jsTypeScriptREST APIsGraphQLMicroservices

Nice-to-have

Azure AI FoundryGenAI-assisted developmentDatabricksData engineering pipelinesDevOpsInfrastructure as CodeMLOpsMicrosoft SQL Server

Soft skills

CommunicationDocumentationCollaboration

LeadFull-StackPythonAI/MLCloud-NativeHybridNetherlandsSoftware Development

/What you'll do

/What you need

Must-have

Nice-to-have

Soft skills

What you'll do

What you need